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Nature 478 , 123126 (2011)

[2] It is a highly conserved system found primarily in animals/some eukaryotes, although bacteria and plants still use carnitine for other things such as being an osmoprotectant, or being and electron acceptor in the electron transport chain

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The pathogenic roles of LMNA (E358K) and LMNA (R453W) were previously reported to cause muscular laminopathy including CMD, EDMD, and EDMD2, our results confirm the pathological roles of LMNA (E358K) and LMNA (R453W) variants and suggest that the novel variants LMNA (L35P) and LMNA (A539V) may also have pathogenic implications