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Strength points and limitations Based on our knowledge, this is the most updated meta-analysis on this topic, including all available evidence based on our inclusion criteria of including only controlled studies, either RCTs or controlled observational studies, to reach the highest accessible quality of evidence from the available evidence found in the literature

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This is because B12 plays a role in the production of neurotransmitters, the chemicals in the brain that regulate mood and emotional well-being

Recent advances in the understanding of the roles gut peptides play in energy homeostasis has led to the identification of several that are known to modulate eating behaviour, including glucagon-like-peptide-1, oxyntomodulin, pancreatic polypeptide and peptide YY 336 , all of which respond to nutrients within the gut, interacting with specific receptors to regulate appetite