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PDGF-BB is a factor with strong chemotactic and mitogenic action on the pericytes while the FGF2 induces proliferation mostly on the endothelium

So, additional investigation is necessary to link these potential associations to konzo pathogenesis, particularly in relation to time of disease onset, as such markers may only be present during early phases of konzo onset when inflammation or neural damage is likely highest

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Pedraz-CuestaEChristensenSJensenAAJensenNFBunchLRomerMUet al

Bioengineered corneal tissue for minimally invasive vision restoration in advanced keratoconus in two clinical cohorts