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Stranges S, Marshall JR, Natarajan R, Donahue RP, Trevisan M, Combs GF (2007) Annals of internal medicine article effects of long-term selenium supplementation on the incidence of type 2 diabetes

Mechanistically, -KG decreases Treg differentiation by inhibiting FOXP3 and upregulating inflammatory cytokines such as IFN-, Tbet, and Rorc, suggesting that Th1-type effector T cells are more dependent on glutaminolysis than Treg cells 136