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Oncol Lett (2019) 17(5):41705

Characterization of the aldose reductase-encoding gene family in rat

While this often leads to desired effects such as long-lasting activity, it can also give rise to significant issues later in the drug discovery pipeline, e.g

Moreover, inflammation-related mechanisms can cause hepatic and splenic macrophages to upregulate erythrophagocytosis and decrease erythrocyte half-life and erythrocyte numbers [119]