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Beyond deacetylation: the non-deacetylase functions of HDACs In addition to the protein deacetylation for HDACs, there are also several evidences showing that HDACs possess deacetylase-independent functions such as sumoylation, decrotonylation, ubiquitin-dependent function and lactylation eraser as shown below

This evolution is driven by selective pressure from antibiotic use, with factors such as decades of overuse, incorrect dosing, and the widespread use of antimicrobials in livestock, contributing to the selection of resistant strains

van der Veen et al., 2017

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