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While the functional significance of this seemingly paradoxical pattern cannot be conclusively established within the scope of the present study, it may tentatively suggest a shift toward the differentiation of CD80/86 monocyte-derived myeloid suppressor cells, potentially associated with the anti-inflammatory action of the treatment

*Comparison based on published research and clinical experience

Besides dendritic spine reduction, the MDD rat model of learned helplessness is also associated with reduced PSD-95 protein levels in the hippocampus (Reins et al., 2008)

Subsequently, mA readers (including YTHDF1-3 and IGF2BP3) recognize the mA modifications on glycolysis-related transcripts and facilitate their transcription, thereby enhancing glycolysis in tumor cells

Taken together, these observations indicate that GPX4 inhibition induces canonical ferroptosis in persister cells