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Interestingly, the PC-mediated detoxification of toxic metal(loid)s is also demonstrated in the fission yeast Schizosaccharomyces pombe [20], in which PCs were first discovered [21], and in the nematode worm Caenorhabditis elegans [22]

257 The pathogenic factors of various organs at the body level and the pathological changes of glial cells at the cellular level should attract more attention to explain the pathogenesis of MDD