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However, as a cautionary note, in patients with SZ, SAMe may at times exacerbate the symptoms of this disease

The resulting S- substituted cysteinylglycines are cleaved by dipeptidase (Reaction 6A) to yield the corresponding S- substituted cysteines, which may undergo N-acetylation (Reaction 8) or an additional transpeptidation reaction to form the corresponding -glutamyl derivative (Reaction 3A)

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Libbey AJ (1986) Determination of ethylene dibromide in aquatic environments

Taken together, the evidence supports the view that both neurons and astrocytes contribute to glutamatergic signaling