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Jalil, A

Patent-Pending SIREN Capsule Technology

doi: 10.1093/oxfordjournals.humrep.a136237 84 YinYDeWolfWCMorgentalerA

have found that temozolomide exposure downregulated the bromodeoxyuridine (BrdU)-positive cell numbers (Nokia et al., 2012)

It is dosed at 10mg twice a day for 8 weeks (this can be further extended for another 8 weeks for a total of 16 weeks if there is partial response), followed by 5mg twice a day for maintenance[102104]