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presented a work based on organoidderived proximal tubule epithelial cells (OPTEC)-on-chip, providing a more sensitive predictor of nephrotoxicity compared to traditional models based on immortalized PTECs (166)

The review also noted that GHK-Cus copper complexation ability raises Cu2+ penetration rates across the stratum corneum, and documented the development of formulation innovations including the TriHex peptide system that combine GHK-Cu-type tripeptides with hexapeptides to produce synergistic upregulation of regenerative genes and suppression of aberrant collagen deposition

The effective concentration sits at levels so small they challenge conventional thinking about dose-response relationships in skincare

Otter S, Lammert E

Int J Radiat Oncol 46:195-205, 2000