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10.3389/fonc.2020.606906 105 MaengH.TerabeM.BerzofskyJ

Carbonated beverages should be ingested sparingly, or not at all, as the body must work to expel the extra ingested carbon dioxide

(2) ROS activates NF-B and MAPK signaling pathways, upregulating the expression of MMPs (MMP-13, MMP-3) and inflammatory factors (IL-1, TNF- ), thereby accelerating the degradation of type II collagen (Col-II) and proteoglycans