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Its nucleocytoplasmic shuttling responds dynamically to osmotic changes, coordinating the expression of genes encoding osmolyte transporters and synthetases that maintain intracellular ionic equilibrium under hypertonic stress [16, 26, 27]

It is a reason to approach it with extreme caution, comprehensive monitoring, and the involvement of qualified medical supervision

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However, we found that four genes, IL-1, IL8, HSPA1A and FOSL1, were significantly induced by CuCl 2 and Cu(OAc) 2 without inhibiting the cell viability