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It contributes to weight gain, obesity, and a number of other diseases like diabetes, heart attacks, and strokes

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We and others also demonstrated that hemin induces the expression of NRF2 in SCD erythroblasts and animal models and such effect is mitigated by administration of dimethyl fumarate (DMF) 23,24 , an FDA-approved drug for the treatment of multiple sclerosis

The major classes of phytochemicals include polyphenols, terpenoids, and steroids, alkaloids, tannins, saponins, and thiols (Zhang et al., 2015)