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There is growing evidence that orally supplied LA may not be used as a metabolic cofactor but instead, elicits a unique set of biochemical activities with potential pharmacotherapeutic value against a host of pathophysiologic insults

& Kranz, C

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Other metals such as Fe, Mn, Al, and Pb also seem to engage in excitotoxicity through regulating intracellular levels of Ca 2+ or related receptor activity