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A deficiency in microbiota diversity may compromise gut barrier integrity, resulting in chronic low-grade inflammation, which is associated with IR, obesity, and elevated triglycerides [121]

2009;Apr 13;169(7):651-8

30 IDH status also influences surgical decisions, with supramaximal resection showing significant benefits in IDH mutant gliomas but a limited impact in IDH wild-type GBMs

We found that hepatic GSH levels were 50% lower in the RXR null mice

Therefore, icariin and icaritin promote the infiltration of immune cells, inhibit various immune checkpoints, reduce the levels of inflammatory cytokines and enhance anti-cancer immunity