PHASE II DRUG METABOLISM: Glucuronidation and SulfationGeneral properties of Phase II metabolismIntroduction to glucuronidationSubstrates for UGTsUGT structureProperties of glucuronidesMethods to characterize glucuronidesDisposition and reactions of glucuronidesUGT pharmacogenetics, polymorphism, variabilitySulfotransferasesN-Acetylation, Aminoacid conjugation, Glutathione conjugationSmith, Phase II Metabolism, UNC Chapel Hill, 8/2012 1 Conjugation Reactions Some DefinitionsGlucuronidation conjugation is the addition of a molecule to the drug or xenobioticGSH conjugation GSH = glutathione (a tripeptide derivative)Sulfate conjugationAmino acid conjugation Some confusing terminology, both related to drugs:Acetylation Phase 1, Phase 2, Phase 3 are designations used in theMethylation sequence of drug development and evaluation by FDA in the US
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High-fat-induced and genetically obese rodents exhibited hepatic insulin resistance and elevated hepatic DAG contents [103,104], and hepatocytes treated with phorbol myristate acetate (PMA, a DAG analog) exhibited impaired IRTK tyrosine kinase activity and insulin-stimulated GYS activity [105]
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There is a lot of interest in ipamorelin because, unlike other growth hormone releasing peptides, it is extremely targeted to growth hormone with minimal effects on other hormones or biochemical processes [3]
