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Additionally, the study noted a possible increase in pituitary RNA and GH mRNA levels following CJC-1295 DAC exposure, suggesting an enhanced presence of somatotroph cellsthose believed to produce growth hormone in the pituitary gland

Curr Biol (2014) 24:R6061

93 After using guinea pig asparaginase 1 (gpASNase1) to promote the conversion of Asn to Asp in tumor cells, the growth rate of tumor cells was significantly increased, suggesting that Asp acquisition is an endogenous metabolic limitation in tumors with difficult Asp acquisition

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By restoring GH and IGF-1 levels to that of young healthy adults, it is likely that a significant amount of muscle and bone degradation could be prevented entirely