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Jermann, P., Hoerner, L., Burger, L

However, more and more challenges are uncovered and discussed below

Jeyaseelan R, Poizat C, Wu HY, Kedes L

For instance, insulin-stimulated hepatocytes display a short-lived ROS burst (mainly HO), which transiently inhibits protein tyrosine phosphatases, thereby enhancing insulin-receptor autophosphorylation and downstream signaling

These enzymes are widely involved in the regulation of many important biological processes including energy metabolism, oxidative stress, inflammation, apoptosis and aging by regulating the acetylation modification state of substrate proteins (Wu et al., 2022)