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Carithers RL Jr, Herlong HF, Diehl AM, Shaw EW, Combes B, Fallon HJ, et al

This cyclical activation and inhibition tightly control NF-B signalling to prevent excessive or inappropriate responses, which could otherwise lead to pathological conditions such as chronic inflammation or cancer [7]

Litwin MS, McNaughton-Collins M, Fowler FJ, Jr

Phase 2 trial data published in 2023 in the New England Journal of Medicine (Jastreboff et al., NEJM 2023) reported mean weight reductions of up to approximately 24% over 48 weeks in adults with obesity notably higher than results seen with currently approved agents

However, our findings did not establish any direct link between HbA 1c levels and spatial task performance, indicating that, in the current era of CGM, patients may exhibit improved HbA 1c control but that glycaemic variability still poses a risk