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doi:10.1016/j.neubiorev.2009.07.005 Wardle, Jon, and Jerome Sarris

In this context, recent studies have affirmed the correlation between cyclophosphamide-induced neurotoxicity with TLR4 activation and the consequent overproduction of pro-inflammatory cytokines and their imperative roles in the pathophysiology of the associated cognitive impairment [32, 43]

doi: 10.3389/fmed.2025.1595568 Received 18 March 2025 Accepted 10 June 2025 Published 25 July 2025 Volume 12 - 2025 Edited by Xiaolei Li, University of Pennsylvania, United States Reviewed by Weili Li, Shandong Academy of Medical Sciences (SDAMS), China Thomas Lindner, Stavanger University Hospital, Norway Updates Copyright 2025 Cheng, Lu, Du, Zhao and Zhuang