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10.1016/j.brs.2018.08.010 Brain Stimul

For example, high mobility group box 1 (HMGB1), as a DAMP, is released in an autophagy-dependent manner by ferroptosis inducers and mediates inflammatory responses through the HMGB1-advanced glycation end-product-specific receptor (AGER) pathway, a pathway that activates the NF-B pathway in innate immunity [94]

Similarly, activated microglia contribute to oxidative stress by upregulating NADPH oxidase 2 (NOX2), which generates O , and inducible nitric oxide synthase (iNOS), which produces nitric oxide (NO)

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While its primary role is blood sugar management, patients often experience weight loss as a secondary benefit