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Ferroptosis can also be triggered by downregulated GPX4 through genetic deletion, covalently inactivating GPX4 (such as RSL3 and ML162) and promoting GPX4 degradation (such as FIN56), whereas overexpressing GPX4 or pharmacologically blocking its degradation may enhance antioxidant capacity and display potent protective effects against ferroptosis (23)

Li IH, Ma KH, Weng SJ, Huang SS, Liang CM, Huang YS (2014) Autophagy activation is involved in 3,4-methylenedioxymethamphetamine (ecstasy)induced neurotoxicity in cultured cortical neurons

9 OFF-LABEL USES OF HYDROQUINONE Disorders of hyperpigmentation including but not limited to chloasma, melasma, ephelides, and solar lentigines 5,6,8 HYDROQUINONE DOSING Topical application to affected areas twice a day

Mechanistically, HT induces ferroptosis via the Nrf2 signaling pathway