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In particular, endothelin receptor antagonists (ERAs) have proven to be an effective therapeutic strategy for slowing kidney function decline in conditions such as type 2 diabetes and IgA nephropathy [174,175,176,177,178,179]

The major contributing factors to such conditions are hormonal changes, friction generated by constrictive garments, shaving, waxing, and skin irritation

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The immobilization enzymes were washed three times with 2 mL of 20 mM potassium phosphate buffer (pH 8.0)