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Glutathione peroxidase (GPx) has important functions in the reduction of peroxides that are reported to inactivate vasodilating NO and the decomposition of S-nitrosoglutathione (GSNO), which plays an important role in vascular homeostasis [79]

Without enough melatonin, these reactive molecules (like amyloid and tau proteins) accumulate, inflaming brain tissue and allowing toxic proteins to clump together

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48 As a result, Hb exhibits limited pseudoperoxidase activity under physiological conditions, offering only modest antioxidative protection

doi: 10.1039/D2RA06023J, 79