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Sub-group analyses supported the use of omega-3 fatty acids (SMD = 0.14, 95% CI = 0.27 to 0.02, p = 0.03) and botanical drug or dietary intervention (SMD = 0.86, 95% CI = 1.58 to 0.13, p = 0.02) among older participants

LC two-sided t-test CD4 T cells p = 0.0076, CD8 T cells p = 0.0182, CD19 B cells p = 0.0842), compared to healthy controls (Supplementary Figure S2)

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Nutrients 13 (8), 2802 (2021)

Other host barriers should also be considered as potential targets for prevention including the oral cavity and lung mucosa as these have been identified as sites of pathogenic autoreactive immune responses that contribute to autoimmune disease