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These effects were also observed in differentiated SH-SY5Y cells incubated with Pb (5100 M/48 h) and analyzed 6 days later (Bihaqi and Zawia, APP expression, as well as reduced expression and protein levels of NEP (an A IDE), suggesting that Pb can target both the synthesis and degradation of A (Huang et al., NEP expression in differentiated SH-SY5Y cells exposed to 50 M Pb, but an increase in APP levels (Chin-Chan et al., LRP1 , resulting in the accumulation of A in the hippocampus and cortex of treated mice (Gu et al., Exposure to Pb during development is a good example of an environmental contaminant as a risk factor to promote neurodegenerative diseases such as AD, supporting the hypothesis that many adult diseases have a fetal origin (FeBAD) (Basha et al., APP mRNA expression as well as in the activity of the transcription factor Sp1 (one of the regulators of APP ) in the cortex of neonates, and after 20 months of Pb exposure had ceased

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