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Among the 25 genes, Slco1a4 , Akr1c19 , and Cyp4f15 are the most downregulated at the RNA level, with Slco1a4 being involved in the transport of bile acids and other monocarboxylic acids ( Figure 4C )

Several nanocarriers (liposomes, nanoparticles) have been studied for their potential to cross the BBB and deliver therapeutic agents directly to affected brain regions

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