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Statistics and reproducibility For all experiments, the data were sampled according to the minimal number of independent replicates that significantly identified an effect (repeating at least three times)

The authors propose that the observed enhancement in NAcc shell dopamine likely reflects general motivational salience, perhaps due to relief from a CS-induced fear state when the US (foot shock) is not delivered

The tablet formulation composition administered to the dog is provided in Table 17

As depicted in Supplementary Figure S3, the conjugation of GHK with RGD made no significant difference in the proteolytic stability of the peptide

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