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The mean age of the children with Down syndrome was 3.6 years (SD 3.33

The major constituents of secondary metabolites are terpenes, alkaloids, and flavonoids derived from leaves, bark, flowers, fruits or seeds, roots [7][Fig

The microbiome is altered in response to genetic influences (Goodrich et al., 2014), environmental factors (Nagpal et al., 2017), and lifestyle (Lee S

Functional screening further identified 9 proteins directly implicated in acne improvement (Table S3)