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Similarly, in this study, the addition of GSH caused auxin input vector AUX related genes to be downregulated, transcription suppressor Aux/IAA to be activated, related genes to be upregulated, and auxin response factor ARF to be inhibited, thus inhibiting auxin signal transduction and improving cadmium tolerance of potato

however, treatment with 100 mg/kg of berberine mitigated this upregulation

Try taking half in the morning and the other half in the early afternoon

Yan et al