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Accordingly, the next generation of clinical research should be designed to test interface quality and robustnessnot only early or late stabilityusing standardized marginal bone change with sufficient follow-up, validated peri-implant inflammatory indices, and biomarker-based endpoints where feasible

Tumor vasculature not only provides necessary oxygen and nutrients to tumor cells but also affects the TME, promoting tumor growth and metastasis

Different compounds which inhibit the Nrf2 pathway are developed and used in the treatment of cancers that act by blocking the synthesis of a protein or decreasing the gene expression and activity of proteasomes or suppressing oxidative stress to inhibit the nucleus translocation of Nrf2 or inhibiting Nrf2-DNA binding (Lin et al., 2020)

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