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first, through the generation of reactive oxygen species (ROS) as a pro-oxidant involving superoxide anions (O 2 -), hydroperoxides (HO), singlet oxygen ( 1 O 2 ) and hydrogen peroxide (H 2 O 2 ) and second, by natural occurring antioxidants capacity destruction (Flora, 2002)

HR 1.19, 95% CI 1.12-1.27, p 0.7)

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doi: 10.1080/19490976.2021.1927633

Zaltoprofen, classified as a non-steroidal anti-inflammatory drug, is an analgesic propionic acid derivative with potent anti-inflammatory and anti-nociceptive properties