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Such studies move closer to the goal of precision therapy for asthma by targeting intracellular nodes, such as ERK1/2, rather than broad anti-inflammatory agents, and hold promise for improved management of severe and therapy-resistant forms of this prevalent and debilitating disease

These results provide strong support for the hypothesis that PDI is a crucial upstream mediator of erastin-induced hepatocyte toxicity in vitro

Advanced formulations utilizing GE11 peptide-conjugated chitosan nanoparticles can specifically target EGFR-overexpressing triple-negative breast cancer cells, leading to the downregulation of miR-21 and inhibition of the AKT/ERK signaling axis (147)

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