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Regulation of this process does not only involve the EC tight junctions

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HFD could also promote the overgrowth of pathogenic bacteria in the intestine and induce the maturation of proinflammatory immune cells, leading to uncontrolled inflammation and mucosal damage indirectly, which were unable to inhibit the overgrowth of pathogenic bacteria, further aggravating the pathophysiological state (Statovci et al., 2017)

*Correspondence: Mauro Magnani, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

They are a blunt instrument: systemic, powerful, and loaded with side effects from acne to liver damage to cardiovascular strain