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107 A statistical analysis of three randomized controlled trials with a combined total of 168 participants found curcumin supplementation, at doses of 5001,500 mg per day, led to improvements in fasting glucose, insulin levels, measures of insulin sensitivity, and HDL- and total cholesterol in women with PCOS

Epidemiology as a guide to clinical decisions

While not universally embraced, its approach, which bases drug consideration on evidence regarding efficacy and safety, has been broadly welcomed by sleep organizations around the world (Ferri 2025)