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Yuste, R

As a long-acting peptide analog, Cagrilintide represents a research subject in the broader field of peptide stability engineering specifically the use of fatty acid acylation strategies to extend peptide half-life and enzymatic resistance compared to native peptide sequences

These studies show that while like CamKII and Cdc42 activities remain highly restricted to the stimulated spine, Rac1 and RhoA activities, like H-Ras, spread into the dendrite and neighboring spines (Murakoshi et al., 2011

General procedure for the synthesis of compounds 5a-5d To a stirred solution of intermediate 4a-4d (1.0 equiv.) in 1,4-dioxane (10 volumes), were added cesium carbonate (3.0 equiv.) and 1-Boc-piperazine (1.5 equiv.) and then degassed the reaction mixture with argon for 5 min