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doi: 10.1016/j.rmed.2011.07.019 102 NevittSJThorntonJMurrayCSDwyerT

As expected, these signals were sensitive to imatinib treatment only in WT-Bcr-Abl-32D cells but not T315I-Bcr-Abl-32D cells, while ponatinib 27 treatment abolished these signals in both cell lines (Supplementary Fig

Flag: RF combined with LED, RF-only effect not isolated

Other technologies, such as adoptive cell therapies, bispecific antibodies and gene editing, have shown promise in animal models, and clinical proof of concept is beginning to emerge 17,18,19,20