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In addition to glutamine, other amino acids play an indispensable role in Teffs as well, which has been comprehensively reviewed recently ( Contrary to conventional effector T cells, an in vitro -induced regulatory T cell fate is favored when oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO) pathways are preferentially engaged in glycolysis ( in vivo exhibit a similar reliance on glycolysis-driven lipogenesis for proliferation and function as Teff cells ( ex vivo display a highly glycolytic phenotype and engage in both glycolysis and FAO when cultured in vitro ( 2.3 Memory T cells (Tm) Four distinct subsets of memory T cells have been characterized based on their phenotype, migration pattern, and functional properties: central memory cells (Tcm), effector memory T cells (Tem), tissue-resident memory T cells (Trm), and stem cell-like memory T-cells (Tscm)