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L-carnitine is primarily synthesized in the liver and transported via the bloodstream to cardiac and skeletal muscle, which rely on L-carnitine for fatty acid oxidation yet cannot synthesize it (8)

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Its prevalence is between 15% and 85% of patients with ALS [84]

Ischemic stroke was obtained from MEGASTROKE consortium (34,217 cases and 406,111 controls) [25], the UK Biobank (7961 cases and 384,003 controls), and Finngen Biobank (10,551 cases and 208,241 controls) [26]

Following intravenous injection of acetyl-l-carnitine, its plasma concentrations increased quickly and then declined, reaching base values within 12 h [41]