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10.1097/pap.0000000000000284 2

6-phosphofructose-2-kinase/fructose-2, 6-bisphosphatase (PFK2) isomer (L-PFK2) was induced by M1 activation, converted into a more active form (u-PFK2), and led to the accumulation of fructose-2, 6-diphosphate, which promoted intracellular aerobic glycolysis ( In brief, we might consider that metabolic events in classically activated macrophages serve a dual purpose: they rapidly provide energy and reduction equivalents to fuel bactericidal activity, and they directly participate in transcriptional regulation to shape immune responses

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Interactions with food (e.g., tyramine reactions) from its weak monoamine oxidase inhibitor activity have also been reported

Zhang Z, Liu J, Shen P, Cao Y, Lu X, Gao X, et al