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No post-hoc data exclusions were made, apart from: (i) applying the a priori predefined inclusion window for metabolomics ( 10% around cohort mean body weight and glycemia) to isolate genotype effects from obesity

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Two days after transfection, luciferase and renilla activity were measured using the Dual-Luciferase Reporter Assay System (Promega, Barcelona, Spain)

For subtype III group, the complement and coagulation cascades were significantly enriched, and the following proteins were enriched: HP, LBP, SERPINA (1, 3), SAA1, CRP, ORM1, ORM2, and CRP