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Results VEGFA is expressed in the lens and the RPE throughout life and increased VEGFA expression correlates with elevation of markers of oxidative stress Here, we utilized a mouse model that has ~two to threefold increased VEGFA levels as a consequence of insertion of a lacZ cassette into the 3UTR of the VEGFA gene that regulates its gene expression (VEGFA hyper mice), reflecting VEGFA increases as they occur in aging conditions induced by increased hypoxia or oxidative damage (Miquerol et al , 1999

Yung LM, Leung FP, Yao X, Chen ZY, Huang Y: Reactive oxygen species in vascular wall

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doi: 10.1186/s12915-018-0507-6 188 YangC.LiG.ZhangQ.BaiW.LiQ.ZhangP.et al

10.1016/j.ejphar.2004.08.055 40 RobertsE.NunesV