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The pentose phosphate pathway in relation to glycolysis, glycogen metabolism and the tricarboxylic acid (TCA) cycle (Litwack et al., 2018) Linking the Pentose Phosphate Pathway and Glutathione Metabolism One fascinating aspect of the pentose phosphate pathway is its direct involvement in the production of NADPH, which plays a crucial role in maintaining cellular redox balance

However, the research in this field is still young, and scientists are yet to unravel potential connections

[DOI] [PubMed] [Google Scholar] Jimenez-Gomez C

While your body can synthesize glutathione, various factors such as aging, stress, chronic alcohol use, poor nutrition, pollution, and certain medical conditions can deplete its levels, making supplementation a popular choice for many seeking to optimize their health

Knockdown of Nrf2 reduces melanocyte viability but not the viability of keratinocytes and fibroblasts, indicating that melanocytes are preferentially dependent on Nrf2 (Pae et al., 2004)