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According to research by Johns Hopkins University, nicotine itself is a toxin which increases blood pressure and spikes adrenaline

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Smokers who are Alpha-1 deficient lose lung function at a faster rate than other smokers

Researchers confined groups of six smokers (who were each provided with ten joints) and six non-smokers in a chamber under both ventilated and unventilated conditions, letting the smokers toke at their leisure for an hour in the company of the non-smokers

Due to the smaller size, the particles comprising Sidestream smoke enter the lungs and bodys cells more easily