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This condition predisposes children to recurrent febrile urinary tract infections and subsequent renal scarring, rather than isolated nocturnal enuresis

Although the specific mechanism is not completely clear at present, from the perspective of its important regulatory role on GABAergic neurons, the abnormality of ARX may affect the normal development and function of GABAergic neurons, leading to the imbalance of brain neural circuits, thus causing ASD related symptoms ( Dysfunction of GABAergic interneurons has been observed in animal models of ASD

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