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4.1 Ferroptosis and ichthyosis Ichthyosis, also referred to as keratosis, is an autosomal dominant genetic disorder characterized by dry, rough, and scaly skin that resembles fish scales (135)

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[114] randomized subjects to semaglutide or placebo to observe the change of liver fat from baseline to week 48, and found that semaglutide significantly reduced hepatic steatosis, improved liver enzymes and metabolic parameters, and had a positive effect on the diagnosis and treatment of NAFLD compared with placebo

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In the first rat models of NP, the expression of ACSL4 was found significantly increased in the spinal cord after SNI, which can be reversed by intrathecal injection of sirtuin 2 (SIRT2) overexpressed recombinant adenovirus, indicating that SIRT2 may achieve a neuroprotective effect via the suppression of ferroptosis (Zhang X

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