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Melnyk et al

CD8(+) T-cell immunity orchestrated by iNKT cells

Besides, 4-HNEs inhibit expression of cyclins D1, D2, and A, and consequently the activity of the cyclin-dependent kinases 4/6 (Cdk4/6) and Cdk2 [124], as well as increase the expression of p21 waf1 , which inhibits the functioning of some cyclin-dependent complexes [125]