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The role of acid-base imbalance in statin-induced myotoxicity

Besides, the most serious barrier to the clinical use of anti-cancer AMPs remains the enzymatic degradation and inactivation of these cytotoxic peptides through interactions with negatively charged serum proteins

While the Lipinskis Rule of Five remains a cornerstone for evaluating oral drug-likeness (molecular weight 5) and failed the Veber, Egan, and Muegge rules owing to its high TPSA and hydrogen-bonding capacity