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Sorafenib therapy in advanced hepatocellular carcinoma: the SHARP trial

Alcohol promotes the production of ROS in various ways: 1) stimulating cytochrome P450s activity, 2) altering certain metal concentrations, 3) decreasing the antioxidants level, 4) directing the conversion of xanthine dehydrogenase (XDO) into xanthine oxidase (XO)